Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates.
نویسندگان
چکیده
A useful Michael addition reaction using nitroalkanes as the nucleophile and 4-oxo-enoates as the Michael acceptor has been disclosed, and the reaction allows expedient access to functionalized chiral gamma-keto esters in high yields and excellent enantioselectivities (up to 98% ee), with a low catalyst loading.
منابع مشابه
Chiral squaramide-catalyzed highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes.
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ورودعنوان ژورنال:
- Chemical communications
دوره 28 شماره
صفحات -
تاریخ انتشار 2009